Shared Research Support Services is happy to announce the purchase of a new MALDI-TOF/TOF Bruker UltrafleXtreme mass spectrometer for the SRSS Mass Spectrometry facility. The mass spec is purchased through the generosity of a NSF Major Research Instrumentation grant with cost sharing provided by the Departments of Chemistry and Biological Sciences and the Office of the Dean. A multidisciplinary team of over 20 user groups was led by PIs Seth Horne, Tara Meyer, and Alex Deiters on the grant submission. The new MALDI will bring a several-generational leap in sensitivity, accuracy, and resolution and its combination of soft laser ionization and MS/MS capabilities allow access to previously inaccessible areas of top down proteomics and sequence deconvolution for proteins and peptides as well as other biomacromolecules and synthetic polymers. The instrument is upgradable to include mass spec imaging of tissue thin sections should the need arise.